Nephrotoxicity of cephaloridine.

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Intraocular penetration of cephaloridine.

Cephaloridine ('Ceporin') is a semisynthetic compound, 7[(2-thienyl)-acetamide]-5(i-pyridylmethyl)-5-cephem-4-carboxylic acid betaine, derived from cephalosporin C. This is an antibiotic produced by Cephalosporium acremonium, a fungus isolated from a sewage outfall off the Sardinian coast (Brotzu, I948). The cephalosporins are closely related chemically to the penicillins in that they contain a...

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The emergence of strains of Neisseria gonorrhoeae relatively resistant to penicillin has created difficulties in the treatment of gonorrhoea (Thayer and Moore, 1964). Progressively larger doses of the drug are required for cure, and if the present trend continues, we may in the near future be faced with strains completely resistant to penicillin. The need to evaluate alternative drugs for treat...

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Cephaloridine in gonorrhoea in females.

Material and Management Cephaloridine ("Ceporin") was used to treat 255 attacks of uncomplicated gonorrhoea (other than gonococcal proctitis) in 234 women. Of these 234 patients, 182 were born in the United Kingdom, 26 were from Southern Ireland, 26 from the West Indies, and the remaining three from India. 34 per cent. of the patients were aged between 13 and 19 years, 31 per cent. between 20 a...

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Penetration of cephaloridine into the subretinal fluid.

Cephaloridine is a wide-spectrum antibiotic derived from cephalosporin and, despite similarities to penicillin, it can be used in the treament of infections in penicillin-sensitive patients. Riley, Boyle, and Leopold (I968) and Records (I969) have reported the intraocular penetration of cephaloridine into the aqueous after intramuscular and intravenous administration, and Moll, Crawford, and Mc...

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ژورنال

عنوان ژورنال: BMJ

سال: 1971

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.4.5779.115-b